尕玉（张磊 饰）本来是个警察，为了调查藏羚羊猎杀状况，他假扮记者身份，随考察团来到可可西里——那里气候寒冷、空气稀薄，含氧量极低
就在这个人类生存的“禁区”，尕玉目睹了一幕幕人性的贪婪以及人类与环境的狂暴冲突 首先是藏羚羊保护站的巡山队员被盗猎人枪杀，接下来他们见到了悲惨的一幕：盗猎者逃走，只留下众多只剩嶙峋白骨的藏羚羊 巡山队员在恶劣的环境中追捕凶手，最终只夺回了一部份的藏羚羊皮毛 一方面要与恶劣的自然环境抗争、另一方面还要与凶残的盗猎者周旋，巡山队员和尕玉面临着生死考验
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